American Airlines, Inc. (AA) is a US-based airline and the world's largest airline in total passengers-miles transported, passenger fleet size, and the second largest airline in terms of aircraft operated (FedEx Express, a cargo airline has more aircraft) and the second-largest airline company in the world (behind Air France-KLM) in terms of total operating revenues.

     American Airlines serves destinations on four continents. Its network is particularly developed in the Americas, where it serves more destinations than any other airline. Hubs at Dallas/Fort Worth, Miami and New York (JFK) serve as major gateways to the Americas, while American's Chicago hub has become the airline's primary gateway to Europe and Asia, and St. Louis is a regional hub for the airline.

    American is the only U.S. airline with scheduled flights to Anguilla, Bolivia, Dominica, Grenada, Saint Vincent and the Grenadines, and Uruguay.

    As of May 2008, American serves 260 cities (excluding codeshares with partner airlines) with a fleet of 655 aircraft.[6] American carries more passengers between the US and Latin America (12.1 million in 2004) than any other airline, and is also strong in the trans/inter/intra/continental market. American has five hubs: Dallas/Fort Worth (DFW), Chicago (ORD), Miami (MIA), Luis Muñoz Marín International Airport (SJU) and Lambert St. Louis International Airport(STL).

    American Airlines is a founding member of the Oneworld airline alliance.